žāV˜a‹v

Kazuhisa Nishizawa, MD, PhD                       

1964       Born in Sapporo,   

1989       Graduated the University of Tokyo School of Medicine,

1989-1993  Graduate School of the University of Tokyo, Department of Neurobiology, The Institute for Brain Research

1993-1995  Research associate,  Department of Biophysics, Teikyo University

1995-1998  Post-doctoral fellow, Immunobiology, Dana-Farber Cancer Institute, Boston

1998-2003  Lecturer at Biochemistry, Teikyo University School of Medicine

2003-2005       Associate Professor of Biochemistry, Teikyo University School of Medicine

2006-       Professor of Clinical Laboratory Science, Teikyo University School of Medical Technology

2006       Chief, Clinical Laboratory Science, Teikyo University School of Medical Technology

 

 

 

Membership and editorial services

 

Feb 2016 onward --   Editor-in-Chief __ Biomedical Research and Clinical Practice (BRCP) __ ---_____http://oatext.com/

 

Mar 2017 onward --  Editor-in-Chief of J. Biophys. Chem.----_____http://www.scirp.org/journal/jbpc/

 

Feb, 2013 onward --  Editorial Board member of_ BioMed Research International__area of computational biology________http://www.hindawi.com/journals/bmri/editors/computational.biology/

 

2012 onward --  Editorial Board member of _______Dataset Papers in Physics (formerly Biophysics)

 

2012 onward -- Editorial Board member of_______ International Scholarly Research Notice --area of Biophysics

 

2010 onward -- Editorial Board member of Computational and Mathematical Methods in Medicine.----________http://www.hindawi.com/journals/cmmm/

 

2010 onward -- Editorial Board member of J. Biophys. Chem.----_____http://www.scirp.org/journal/jbpc/

 

 

 

 

Publication list

 

Manami Nishizawa and Kazuhisa Nishizawa

Be straight to better coordinate two -- head groups and extended acyl chains of raft-like bilayer lipids can localize in groove between dimerized transmembrane helical peptides and assist sequence-nonspecific stabilization of peptide dimers by cholesterol

Biomedical Research and Clinical Practice  (2017)@ in press

 

Manami Nishizawa and Kazuhisa Nishizawa

Commentary---Why have cholesterol and saturated fatty acids acquired proinflammatory roles during evolution? – A hypothesis from atomistic simulations showing sequence-nonspecific stabilization of peptide dimers in lipid raft-like bilayers

Biomedical Research and Clinical Practice  (2017)@ 2 (2):1-6  DOI: 10.15761/BRCP.1000137

 

Manami Nishizawa and Kazuhisa Nishizawa

Cholesterol and saturated fatty acid stabilize dimerization of helical transmembrane peptides by lowering energy cost related to peptides desolvation from lipids upon dimerization: an insight from atomistic simulation

Biomedical Research and Clinical Practice  (2017)  2:1-8    doi: 10.15761/BRCP.1000131

 

Reiko Seki and Kazuhisa Nishizawa

Factors regulating Th17: a review

Biomedical Research and Clinical Practice (2016)  1 :4: 126-147  DOI:10.15761/BRCP.1000122@

 

Gnanasambandam R., C. Ghatak, A. Yasmann, K, Nishizawa, F. Sachs, A.S. Ladokhin, S. Sukharev, T.M. Suchyna@@

GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels

Biophys J__2017 ;112(1):31-45.

 

Kazuhisa Nishizawa and Reiko Seki

Mechanisms of immunosuppression by mesenchymal stromal cells: a review with a focus on molecules

Biomedical Research and Clinical Practice__(2016)  1(3):82-96; doi: 10.15761/BRCP.1000116

 

Nishizawa K

Low-grade endotoxemia, diet, and gut microbiota – an emphasis on the early events leading to dysfunction of the intestinal epithelial barrier -review article

Biomedical Research and Clinical Practice@ (2016)  1(2)  DOI: 10.15761/BRCP.1000110 

 

Nishizawa K

Biomedical research and clinical practice - open access - editorial for the inaugural issue

Biomedical Research and Clinical Practice  (2016)@ 1:  DOI: 10.15761/BRCP.1000101 

 

Nishizawa M, Nishizawa K

Free energy of helical transmembrane peptide dimerization in OPLS-AA/Berger force field simulations: inaccuracy and implications for partner-specific Lennard-Jones parameters  between peptides and lipids

Molecular Simulation  (2016)  42: 916-926

 

Kazuhisa Nishizawa; Manami Nishizawa; Radhakrishnan Gnanasambandam; Frederick Sachs; Sergei I Sukharev, Thomas M. Suchyna

Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations

Biochimica et Biophysica Acta (BBA) - Biomembranes  (2015) 1848:_ 2767-2778

 

Nishizawa, M, Nishizawa, K

Potential of mean force analysis of the self-association of leucine-rich transmembrane ƒŋ-helices: difference between atomistic and coarse-grained simulations.

J Chem Phys. (2014)  141 : 075101

 

Nishizawa M, Nishizawa K

Molecular Dynamics Simulation Analysis of Membrane Defects and Pore Propensity of Hemifusion Diaphragms.

Biophys J  (2013)  104: 1038-1048,

 

Nishizawa M and Nishizawa K 

Coarse-grained simulations of branched bilayer membranes: effects of

cholesterol-dependent phase separation on curvature-driven lipid sorting  

J Biophys Chem (2011)  2 : 268-284    DOI: 10.4236/jbpc.2011.23032  

 

Nishizawa M and Nishizawa K  

Curvature-driven lipid sorting: coarse-grained dynamics simulations of a membrane mimicking a hemifusion intermediate

J Biophys Chem (2010)   1:86-95

 

Nishizawa M, Nishizawa K

Molecular dynamics simulation analyses of viral fusion peptides in membranes prone to phase transition:

effects on membrane curvature, phase behavior and lipid-water interface destabilization.

J Biophys Chem (2010)   1:19-32

 

Nishizawa M, Nishizawa K

Coupling of S4 helix Translocation and S6 Gating Analyzed by Molecular Dynamic Simulations of Mutated Kv channels

Biophys J  (2009)    97: 90-100

 

Nishizawa M, Nishizawa K

Molecular Dynamics Simulation of Kv channel Voltage Sensor Helix in a Lipid Membrane with Applied Electric Field.

Biophys J  (2008)@ 95:1729-1744

 

Nishizawa M, Nishizawa K.

Molecular Dynamics Simulations of a Stretch-Activated Channel Inhibitor GsMTx4 with Lipid Membranes: Two Binding Modes and Effects of Lipid Structure.

Biophys J  (2007)   92: 4233-4243

 

Nishizawa M, Nishizawa K

Interaction between K+ Channel Gate Modifier Hanatoxin and Lipid Bilayer Membranes Analyzed by Molecular Dynamics Simulation.

Eur Biophys J  (2006)  35: 373-381

 

Nishizawa M, Nishizawa K.

 On slippage-like mutation dynamics within genes: a study of pseudogenes and 3'UTRs.

J Mol Evol. (2005) 60:274-275.

 

 

M Nishizawa and K Nishizawa

A DNA sequence evolution analysis generalized by simulation and the Markov chain Monte Carlo method implicates strand slippage in a majority of insertions and deletions.
J Mol Evol.   55: 706-717.(2002)

 

Wada Y, Yamashita T, Imai K, Miura R, Takao K, Nishi M, Takeshima H, Asano T, Morishita R, Nishizawa K, Kokubun S, Nukada T.

 A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K(+) channels by G-protein betagamma-subunits.

EMBO J. i2000j@19: 4915-4925. 

 

M. Nishizawa and K. Nishizawa

Amino acid and nucleotide recurrence in aligned sequences: synonymous substitution patterns in association with global and local base compositions

Nucleic Acids Res.  28: 3801-3810. (2000)

 

K. Nishizawa, M. Nishizawa and Ki Seok Kim

Tendency for local repetitiveness in amino acid usages in modern human proteins

J Mol Biol 294, 937-953 (1999)

@

M. Nishizawa and K. Nishizawa

Local repetitiveness in amino acids usages in protein sequences - a genomic factor for protein evolution

Proteins 37, 284-292 (1999)

 

Freund C, Dotsch V, Nishizawa K, Reinherz EL, Wagner G

The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.

Nat Struct Biol 6:656-60 (1999)

@

Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL

A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.

EMBO J 17,7320-7336 (1998)

 

Kazuhisa Nishizawa, Christian Freund, Jing Li, Gerhard Wagner and Ellis L.Reinherz.

Identification of a novel proline-binding motif regulating CD2-triggered T lymphocyte activation.

Proc Natl Acad Sci USA 95,14897-902.(1998)

 

M. Nishizawa and K. Nishizawa

Biased usages of arginines and lysines in proteins are correlated with local-scale fluctuations of G+C content of DNA sequences.

J Mol Evol, 47, 385-93. (1998)

 

Kazuhisa Nishizawa and Shigeo Koyasu

IL-2 and IL-7 differentially induce CD4-CD8- ab TCR NK1.1+ large granular lymphocytes and IL-4 producing T cells from CD4-CD8- ab TCR+ NK1.1- cells:implications for the regulations of Th1 and Th2 type responces.

International Immunology, 9, 1123-1129 (1997)

@

Nishizawa K, Okado H and Okamoto H

An immunocytochemical technique for analysis of regulation of genes encoding early differentiation marker antigens in an oocyte translation system.

Biotech Histochem. 71, 73-78. (1996)

 

Nishizawa K, Shimoda E and Kasahara M

Substrate recognition domain of the Gal2 galactose transporter in yeast Saccharomyces cerevisiae as revealed by chimeric galactose-glucose transporters.

J Biol Chem. 270, 2423-2426. (1995)

 

Nishizawa K and Okamoto H

Mutation analysis of the role for the carboxy-terminus encoding region in NGF-induced stabilization of GAP-43 mRNA.

Biochem Biophys Res Commun. 205, 1380-1385. (1994)

@

Nishizawa K.

NGF-induced stabilization of GAP-43 mRNA is mediated by both 3' untranslated region and a segment encoding the carboxy-terminus peptide.

Biochem Biophys Res Commun. 200, 789-796. (1994)

@

 

iReview articles of earlier publicationj

Nishizawa K.

Control of stability of eukaryote mRNA--3' untranslated region as a program for degradation

Tanpakushitsu Kakusan Koso. (1995) 40, 1092-1099.

@

Nishizawa K.

Translation and Control of stability of mRNAs

in New development of Molecular Biology. M. Muramatsu ed. (1998) Asakura Press, Tokyo, Japanese.

@

Nishizawa K.

Gene control, Translation etc

Dictionary of Molecular and Cellular Biology. (1997) Tokyo-Kagaku-Dojin,

Tokyo, Japanese.

 

Nishizawa K.

Local repetitiveness and slippage-like mutations in genomic sequences.

Recent Research Developments in Molecular Biology  1,145-164 (2003) ,

http://www.researchsignpost.com  

 

Nishizawa K

Molecular Dynamics Simulations of Kv Channels and Gating-Modifier Peptide Toxins

Current Computer-Aided Drug Design  (2009) 5:155-173

 

Nishizawa K. Atomistic molecular simulation of gating modifier venom peptides: two binding modes and effects of lipid structure.

 in Mechanosensitivity of Cells and Tissues: Mechanosensititvity and Mechanotransduction by Andre Kamkin ed @(2010)

 

 

 

 

 

 

Teaching experiences

2006- Biochemistry, Clinical Chemistry, Analytical Chemistry, Special course of Clinical laboratory science I and II, Training course of Biochemistry,

Prior to 2006 when Dept of Clinical Lab Science was launched, I had class on Biochemistry, Medical English, and Cellular Biomedicine in Teikyo Univ School of Med.

 

 

 

Education of postgraduates (Master and Doctoral courses)

-- 2016, currently teaching one post-graduate toward her doctoral thesis work

-- 2013-  Classes on molecular metabolisms and clinical chemistry.