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žāVav
Kazuhisa Nishizawa, MD,
PhD
1964 Born in
Sapporo,
1989
Graduated the University of Tokyo School of Medicine,
1989-1993 Graduate School
of the University of Tokyo, Department of Neurobiology, The Institute for Brain
Research
1993-1995 Research
associate, Department of
Biophysics, Teikyo University
1995-1998 Post-doctoral
fellow, Immunobiology, Dana-Farber Cancer Institute, Boston
1998-2003 Lecturer at
Biochemistry, Teikyo University School of Medicine
2003-2005 Associate
Professor of Biochemistry, Teikyo University School of Medicine
2006- Professor
of Clinical Laboratory Science, Teikyo University School of Medical Technology
2006
Chief, Clinical Laboratory Science, Teikyo University School of Medical
Technology
Membership and editorial services
Dec
2017 onward -- Editor in
Chief ___ Annals of Biomedical Research
(ABR) __
http://escires.com/annals-of-biomedical-research
Feb 2016 - June 2018
-- Editor-in-Chief __ Biomedical
Research and Clinical Practice (BRCP)
Mar 2017 onward --
Editor-in-Chief of J.
Biophys. Chem.----_____http://www.scirp.org/journal/jbpc/
Feb, 2013 onward
-- Editorial Board member of_ BioMed
Research International__area of
computational biology________http://www.hindawi.com/journals/bmri/editors/computational.biology/
2012 onward -- Editorial Board member of _______Dataset Papers in Physics (formerly
Biophysics)
2010 onward --
Editorial Board member of Computational and Mathematical Methods in
Medicine.----________http://www.hindawi.com/journals/cmmm/
Publication list
[ Computational studies on TM dimerization ]
Kazuhisa Nishizawa, Manami Nishizawa
Atomistic simulation analyses of
sequence-nonspecific effects of lipid composition on transmembrane helical
peptide dimerization
Annals
of Biomedical Research 2019, 2:114 (Open Access)
Manami
Nishizawa and Kazuhisa Nishizawa
Annals
of Biomedical Research 2018, 1: 113 (Open Access)
Manami
Nishizawa and Kazuhisa Nishizawa
Annals
of Biomedical Research 2018, 1: 112 (Open Access)
Manami
Nishizawa and Kazuhisa Nishizawa
Annals
of Biomedical Research 2018 1: 106@ Word format is: http://gen.g.dgdg.jp/ABR-ms-1-106.pdf
Manami
Nishizawa and Kazuhisa Nishizawa
Annals
of Biomedical Research 2018, 1: 105@Word format is: http://gen.g.dgdg.jp/ABR-ms-1-105.pdf
Manami
Nishizawa and Kazuhisa Nishizawa
Cholesterol
and saturated fatty acid stabilize dimerization of helical transmembrane
peptides by lowering energy cost related to peptides desolvation from lipids
upon dimerization: an insight from atomistic simulation
Biomedical
Research and Clinical Practice (2017)
2:1-8 doi:
10.15761/BRCP.1000131
Nishizawa M, Nishizawa K
Free energy of
helical transmembrane peptide dimerization in OPLS-AA/Berger force field
simulations: inaccuracy and implications for partner-specific Lennard-Jones
parameters between peptides and
lipids
Molecular
Simulation (2016) 42: 916-926
Nishizawa, M, Nishizawa, K
Potential of mean force analysis of the
self-association of leucine-rich transmembrane ŋ-helices: difference
between atomistic and coarse-grained simulations.
J Chem Phys. (2014) 141 :
075101
[Other topics]
Kazuhisa
Nishizawa, Reiko Seki
Epidemiological
Studies of Uric Acid: A Mini-review with a Focus on Mendelian
Randomization
Annals of Biomedical Research 2020,
3(1): 119
Reiko
Seki, Kazuhisa Nishizawa
Neutrophil
extracellular trap formation after sterile insults in lung, liver, heart and
kidney: a mini-review
Annals of Biomedical Research 2019,
2(1): 117
A Kawanabe, M Hashimoto, M Nishizawa, K
Nishizawa, H Narita, T Yonezawa, Y Jinno, S Sakata, A Nakagawa and Y
Okamura. The hydrophobic
nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing
phosphatase
eLife 2018: e41653
Kazuhisa Nishizawa and Manami Nishizawa
Annals
of Biomedical Research 2018,
1:109@__ http://escires.com/articles/ABR-1-109.pdf
Reiko Seki and Kazuhisa Nishizawa
Inflammatory vs thrombotic
states of platelets: a mini-review with a focus on functional dichotomy
Annals
of Biomedical Research 2018 1: 107
http://escires.com/articles/ABR-1-107.pdf
Manami Nishizawa and Kazuhisa Nishizawa
Pirfenidone, fluorofenidone and new
antifibrotic drugs: biochemistry of direct and indirect effects.
Annals
of Biomedical Research 2018;
1:101 __
http://escires.com/articles/ABR-1-101.pdf
Manami
Nishizawa and Kazuhisa Nishizawa
Commentary---Why have cholesterol and
saturated fatty acids acquired proinflammatory roles during evolution? – A
hypothesis from atomistic simulations showing sequence-nonspecific
stabilization of peptide dimers in lipid raft-like bilayers
Biomedical
Research and Clinical Practice (2017)@ 2
(2):1-6 DOI: 10.15761/BRCP.1000137
Reiko Seki and Kazuhisa Nishizawa
Factors regulating Th17: a review
Biomedical
Research and Clinical Practice (2016) 1 :4: 126-147 DOI:10.15761/BRCP.1000122@
Gnanasambandam R., C. Ghatak, A. Yasmann,
K, Nishizawa, F. Sachs, A.S. Ladokhin, S. Sukharev, T.M. Suchyna@@
GsMTx4: Mechanism of Inhibiting
Mechanosensitive Ion Channels
Biophys
J__2017 ;112(1):31-45.
Kazuhisa Nishizawa and Reiko Seki
Mechanisms of immunosuppression by
mesenchymal stromal cells: a review with a focus on molecules
Biomedical
Research and Clinical Practice__(2016) 1(3):82-96; doi:
10.15761/BRCP.1000116
Nishizawa K
Low-grade endotoxemia, diet, and gut
microbiota – an emphasis on the early events leading to dysfunction of the
intestinal epithelial barrier -review article
Biomedical
Research and Clinical Practice@ (2016) 1(2) DOI: 10.15761/BRCP.1000110
Nishizawa K
Biomedical research and clinical practice -
open access - editorial for the inaugural issue
Biomedical
Research and Clinical Practice (2016)@ 1:
DOI: 10.15761/BRCP.1000101
Kazuhisa Nishizawa; Manami Nishizawa;
Radhakrishnan Gnanasambandam; Frederick Sachs; Sergei I Sukharev, Thomas M.
Suchyna
Effects of Lys to Glu mutations in GsMTx4
on membrane binding, peptide orientation, and self-association propensity, as
analyzed by molecular dynamics simulations
Biochimica
et Biophysica Acta (BBA) - Biomembranes (2015) 1848:_ 2767-2778
Nishizawa M, Nishizawa K
Molecular Dynamics Simulation Analysis
of Membrane Defects and Pore Propensity of Hemifusion Diaphragms.
Biophys J (2013) 104: 1038-1048,
Nishizawa M and Nishizawa K
Coarse-grained simulations of branched bilayer membranes: effects of
cholesterol-dependent phase separation on curvature-driven lipid
sorting
J Biophys Chem (2011) 2 : 268-284 DOI: 10.4236/jbpc.2011.23032
Nishizawa M and
Nishizawa K
Curvature-driven
lipid sorting: coarse-grained dynamics simulations of a membrane mimicking a
hemifusion intermediate
J Biophys Chem (2010) 1:86-95
Nishizawa
M, Nishizawa K
Molecular dynamics simulation analyses of
viral fusion peptides in membranes prone to phase transition:
effects on membrane curvature, phase
behavior and lipid-water interface destabilization.
J Biophys Chem (2010) 1:19-32
Nishizawa
M, Nishizawa K
Coupling
of S4 helix Translocation and S6 Gating Analyzed by Molecular Dynamic
Simulations of Mutated Kv
channels
Biophys
J (2009) 97: 90-100
Nishizawa
M, Nishizawa K
Molecular Dynamics Simulation of Kv channel Voltage
Sensor Helix in a Lipid Membrane with Applied Electric Field.
Biophys J (2008)@ 95:1729-1744
Nishizawa
M, Nishizawa K.
Molecular
Dynamics Simulations of a Stretch-Activated Channel Inhibitor GsMTx4 with Lipid
Membranes: Two Binding Modes and Effects of Lipid Structure.
Biophys J (2007) 92: 4233-4243
Nishizawa M,
Nishizawa K
Interaction
between K+ Channel Gate Modifier Hanatoxin and Lipid Bilayer Membranes Analyzed
by Molecular Dynamics Simulation.
Eur Biophys J
(2006) 35: 373-381
Nishizawa M, Nishizawa K.
On
slippage-like mutation dynamics within genes: a study of pseudogenes and
3'UTRs.
J Mol Evol. (2005) 60:274-275.
M Nishizawa and K Nishizawa
A DNA sequence evolution analysis generalized by simulation and the
Markov chain Monte Carlo method implicates strand slippage in a majority of
insertions and deletions.
J Mol Evol. 55:
706-717.(2002)
Wada Y,
Yamashita T, Imai K, Miura R, Takao K, Nishi M, Takeshima H, Asano T, Morishita
R, Nishizawa K, Kokubun S, Nukada T.
A region of the sulfonylurea receptor
critical for a modulation of ATP-sensitive K(+) channels by G-protein
betagamma-subunits.
EMBO J. i2000j@19: 4915-4925.
M. Nishizawa and K. Nishizawa
Amino acid and nucleotide recurrence in aligned sequences: synonymous substitution patterns in association with global and local base compositions
Nucleic
Acids Res. 28: 3801-3810. (2000)
K. Nishizawa, M. Nishizawa and Ki Seok Kim
Tendency for local repetitiveness in amino acid usages in modern human
proteins
J
Mol Biol 294, 937-953 (1999)
@
M. Nishizawa and K. Nishizawa
Local repetitiveness in amino acids usages in protein sequences - a
genomic factor for protein evolution
Proteins 37, 284-292 (1999)
Freund C, Dotsch V, Nishizawa K, Reinherz EL, Wagner G
The GYF domain is a novel structural fold that is involved in lymphoid
signaling through proline-rich sequences.
Nat
Struct Biol 6:656-60 (1999)
@
Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R,
Sunder-Plassmann R, Reinherz EL
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2
cytoplasmic domain and regulates CD2-triggered adhesion.
EMBO
J 17,7320-7336 (1998)
Kazuhisa Nishizawa, Christian Freund, Jing Li, Gerhard Wagner and Ellis
L.Reinherz.
Identification of a novel proline-binding motif regulating
CD2-triggered T lymphocyte activation.
Proc
Natl Acad Sci USA 95,14897-902.(1998)
M. Nishizawa and K. Nishizawa
Biased usages of arginines and lysines in proteins are correlated with
local-scale fluctuations of G+C content of DNA sequences.
J
Mol Evol, 47, 385-93. (1998)
Kazuhisa Nishizawa and Shigeo Koyasu
IL-2 and IL-7 differentially induce CD4-CD8- ab TCR NK1.1+ large
granular lymphocytes and IL-4 producing T cells from CD4-CD8- ab TCR+ NK1.1-
cells:implications for the regulations of Th1 and Th2 type responces.
International
Immunology, 9, 1123-1129 (1997)
@
Nishizawa K, Okado H and Okamoto H
An immunocytochemical technique for analysis of regulation of genes
encoding early differentiation marker antigens in an oocyte translation system.
Biotech
Histochem. 71, 73-78. (1996)
Nishizawa K, Shimoda E and Kasahara M
Substrate recognition domain of the Gal2 galactose transporter in yeast
Saccharomyces cerevisiae as revealed by chimeric galactose-glucose
transporters.
J
Biol Chem. 270, 2423-2426. (1995)
Nishizawa K and Okamoto H
Mutation analysis of the role for the carboxy-terminus encoding region
in NGF-induced stabilization of GAP-43 mRNA.
Biochem
Biophys Res Commun. 205, 1380-1385.
(1994)
@
Nishizawa K.
NGF-induced stabilization of GAP-43 mRNA is mediated by both 3'
untranslated region and a segment encoding the carboxy-terminus peptide.
Biochem
Biophys Res Commun. 200, 789-796.
(1994)
@
iReview articles of earlier publicationj
Nishizawa K.
Control of stability of eukaryote mRNA--3' untranslated region as a
program for degradation
Tanpakushitsu Kakusan Koso. (1995) 40, 1092-1099.
@
Nishizawa K.
Translation and Control of stability of mRNAs
in New development of Molecular Biology. M. Muramatsu ed. (1998)
Asakura Press, Tokyo, Japanese.
@
Nishizawa
K.
Gene control, Translation etc
Dictionary of Molecular and Cellular Biology. (1997) Tokyo-Kagaku-Dojin,
Tokyo, Japanese.
Nishizawa K.
Local repetitiveness and slippage-like
mutations in genomic sequences.
Recent Research Developments
in Molecular Biology 1,145-164 (2003) ,
http://www.researchsignpost.com
Nishizawa K
Molecular Dynamics Simulations of Kv Channels
and Gating-Modifier Peptide Toxins
Current Computer-Aided Drug
Design
(2009) 5:155-173
Nishizawa K. Atomistic molecular simulation
of gating modifier venom peptides: two binding modes and effects of lipid structure.
in
Mechanosensitivity of Cells and Tissues: Mechanosensititvity and
Mechanotransduction by Andre Kamkin ed @(2010)
Teaching experiences
2006- Biochemistry, Clinical Chemistry,
Analytical Chemistry, Special course of Clinical laboratory science I and II,
Training course of Biochemistry,
Prior to 2006 when Dept of Clinical Lab
Science was launched, I had class on Biochemistry, Medical English, and
Cellular Biomedicine in Teikyo Univ School of Med.
Education of postgraduates (Master and Doctoral courses)
-- 2016, currently teaching one post-graduate
toward her doctoral thesis work
-- 2013-
Classes on molecular metabolisms and clinical chemistry.